Sodium Iodide → 5-Chloro-1-(3-iodopropyl)indole-3-carboxaldehyde
반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][CH2:12][CH2:13]Cl)[CH:6]=[C:5]2[CH:15]=[O:16].[I-:17].[Na+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][CH2:12][CH2:13][I:17])[CH:6]=[C:5]2[CH:15]=[O:16]참가 물질
4
실험 절차
A stirred solution of 5-chloro-1-(3-chloropropyl)indole-3-carboxaldehyde (3.8 g, 15 mmol) and sodium iodide (4.5 g, 30 mmol) in acetonitrile (50 mL) under argon was heated under reflux for 18 h, cooled to room temperature and partitioned between ether (3×30 mL) and water (50 mL). The combined organic extracts were washed (aqueous sodium metabisulfite solution, water, brine), dried (sodium sulfate) and concentrated in vacuo to give the product as a yellow oil (5.0 g, 96%) which was used immediately.
후처리
- temperatureunder reflux for 18 h
- custompartitioned between ether (3×30 mL) and water (50 mL)
- washThe combined organic extracts were washed (aqueous sodium metabisulfite solution, water, brine)
- dry with materialdried (sodium sulfate)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-0e7782ec23d24cd682978a095c17b783
- 출처 데이터셋
- uspto-grants-2002_08
- 특허 번호
- US06433175B1
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