Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,6-Dichloro-5-(4-methylphenyl)pyrimidine → 4-Amino-6-chloro-5-(4-methylphenyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,6-Dichloro-5-(4-methylphenyl)pyrimidine | HCID 21979554 | — |
| 반응물 | Ethanol, reaction products with ammonia, distn. residues | HCID 22020343 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-Amino-6-chloro-5-(4-methylphenyl)pyrimidine | HCID 18931100 | — |
반응 단계
To a solution of 4,6-dichloro-5-(4-methylphenyl)pyrimidine (4.14 g) in ether (20 ml) is added 27% ammonia-ethanol solution (30 ml), and the reaction mixture is reacted at room temperature in a sealed tube for three days. The mixture is concentrated under reduced pressure, and the residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=(10:1)~ethyl acetate) to give 6-chloro-5-(4-methylphenyl)pyrimidin-4-amine (1.89 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728706 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-bd67cbfc2bdf4149825d464041c6164c |
| 출처 메모 | uspto-grants-1998_03 |