Etodroxizine → Norchlorcyclizine

HRID 2304468노트

반응식

HRID 2304468 반응식
C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[N:23]2[CH2:28][CH2:27][N:26](CCOCCOCCO)[CH2:25][CH2:24]2)=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([CH:22]([C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=2)[N:23]2[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]2)=[CH:20][CH:21]=1

참가 물질

3

반응물 2

HCID 63345Etodroxizine2회HCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride

생성물 1

HCID 9340Norchlorcyclizine

실험 절차

dextrorotatory dihydrochloride of 2-[2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethoxy]ethanol (compound J, prepared in Example 5.8);

출처 및 근거

ORD 기록
ord-da525776f36d4104ae7ce38bf2120763
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06436942B1

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