Water → N-[5-Phenyl-4-(3-pyridyl)-1,3-thiazol-2-yl]acetamide

HRID 2304606노트

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HRID 2304606 반응식
[C:1]1([C:7]2[S:11][C:10]([NH2:12])=[N:9][C:8]=2[C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:19](Cl)(=[O:21])[CH3:20].O>CN(C)C(=O)C>[C:1]1([C:7]2[S:11][C:10]([NH:12][C:19](=[O:21])[CH3:20])=[N:9][C:8]=2[C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 9794996[5-Phenyl-4-(3-pyridyl)-1,3-thiazol-2-yl]amine

생성물 1

HCID 22993726N-[5-Phenyl-4-(3-pyridyl)-1,3-thiazol-2-yl]acetamide수율 59%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

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온도
80 °C

실험 절차

To a solution of [5-phenyl-4-(3-pyridyl)-1,3-thiazol-2-yl]amine (1.10 g, 4.34 mmol) in N,N-dimethylacetamide (20 mL) was added acetyl chloride (680 mg, 8.68 mmol) and stirred at 80° C. for 3 h. Water was added to the reaction mixture and extracted with ethyl acetate twice. The combined organic phases were washed with water, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized from chloroform-ethyl ether to give the title compound (750 mg, yield 59%).

후처리

  1. extractionextracted with ethyl acetate twice
  2. washThe combined organic phases were washed with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was recrystallized from chloroform-ethyl ether

출처 및 근거

ORD 기록
ord-efaf2f3515e045268fab138e9808aadf
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06436966B1

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