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Dimethyl methylphosphonate → 1,1-Difluoro-3-amino-3-hydroxymethyl-5-(4-octylphenyl)pentylphosphonic acid

HRID 2304993
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반응식

HRID 2304993 반응식
[NH2:1][C:2]([CH2:21]O)([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:9][CH:8]=1)[CH2:3][OH:4].[Li].C([Li])CCC.[F:29][CH:30]([P:32](=[O:39])([O:36]CC)[O:33]CC)[F:31].CP(=O)(OC)OC>>[F:29][C:30]([P:32](=[O:33])([OH:39])[OH:36])([F:31])[CH2:21][C:2]([NH2:1])([CH2:3][OH:4])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:9][CH:8]=1
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참가 물질

6

반응물 5

HCID 12958Dimethyl methylphosphonateHCID 107970FingolimodHCID 2758305Phosphonic acid, (difluoromethyl)-, diethyl esterHCID 3028194LithiumHCID 178418339Butyllithium

생성물 1

HCID 102023641,1-Difluoro-3-amino-3-hydroxymethyl-5-(4-octylphenyl)pentylphosphonic acid

실험 절차

The title compound was prepared from 2-amino-2-hydroxymethyl-4-(4-(octyl)phenyl)butanol (FrY 720) using procedures analogous to those described in EXAMPLE 2, except that lithium dilsopropylamide was substituted for n-butyllithium in Step C and diethyl difluoromethylphosphonate was substituted for dimethyl methylphosphonate in Step C: Mass spectrum (NH3—CI) 422 (M+H).

출처 및 근거

ORD 기록
ord-d345444460274bfca6870ab5e5a72191
출처 데이터셋
uspto-grants-2002_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06437165B1

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