3-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl ester → 2-Ethoxy-3-(4-hydroxy-phenyl)-propionic acid methyl ester

HRID 2305318노트

반응식

HRID 2305318 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:21][CH2:22][CH3:23])[C:17]([O:19][CH3:20])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([O:21][CH2:22][CH3:23])[C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:14]=1

참가 물질

5

반응물 2

HCID 219309623-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 149239942-Ethoxy-3-(4-hydroxy-phenyl)-propionic acid methyl ester수율 84%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A suspension of methyl 3-[4-benzyloxyphenyl)-2-ethoxypropanoate (3.7 g, 11.78 mmol; preparation 2) and 10% Pd-C (0.37 g) in ethyl acetate (50 mL) was stirred at 25° C. under 60 psi hydrogen pressure for 24 h. The catalyst was filtered and the solvent was evaporated under reduced pressure. The residue was chromatographed over silica gel using a mixture of ethyl acetate and pet. ether (2:8) as an eluent to afford the title compound (2.2 g, 84%) as an oil.

후처리

  1. filtrationThe catalyst was filtered
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was chromatographed over silica gel using
  4. additiona mixture of ethyl acetate and pet. ether (2:8) as an eluent

출처 및 근거

ORD 기록
ord-880a37afa876453aa2d6230c274b3e7f
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06440961B1

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