1,3-Diamino-2-propanol → (RS)-1-Amino-3-[[2-(4-chlorophenyl)-4-quinolinyl]amino]-2-propanol dihydrochloride

반응식

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[CH:3]=1.[NH2:19][CH2:20][CH:21]([OH:24])[CH2:22][NH2:23]>>[ClH:1].[ClH:1].[NH2:19][CH2:20][CH:21]([OH:24])[CH2:22][NH:23][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[CH:3]=1

참가 물질

반응물 2

HCID 611571,3-Diamino-2-propanol

HCID 112195464-Chloro-2-(4-chlorophenyl)quinoline

생성물 1

HCID 18433049(RS)-1-Amino-3-[[2-(4-chlorophenyl)-4-quinolinyl]amino]-2-propanol dihydrochloride

실험 절차

The title compound, m.p. 283-287° C., and MS: m/e=328.2 (M+H+), was prepared from 4-chloro-2-(4-chloro-phenyl)-quinoline and 1,3-diamino-2-propanol.

출처 및 근거

ORD 기록: ord-7cb60a660f5449f69343a7e745b02eae
출처 데이터셋: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06440995B1

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