Methyl 3-methyl-4-(2-methoxy-5-nitrophenoxy)butyrate → Methyl 3-methyl-4-(2-methoxy-5-aminophenoxy)butyrate

HRID 2305630노트

반응식

HRID 2305630 반응식
[CH3:1][CH:2]([CH2:8][O:9][C:10]1[CH:15]=[C:14]([N+:16]([O-])=O)[CH:13]=[CH:12][C:11]=1[O:19][CH3:20])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[H][H]>CO.[Pd]>[CH3:1][CH:2]([CH2:8][O:9][C:10]1[CH:15]=[C:14]([NH2:16])[CH:13]=[CH:12][C:11]=1[O:19][CH3:20])[CH2:3][C:4]([O:6][CH3:7])=[O:5]

참가 물질

5

반응물 2

HCID 18433387Methyl 3-methyl-4-(2-methoxy-5-nitrophenoxy)butyrateHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 11322746Methyl 3-methyl-4-(2-methoxy-5-aminophenoxy)butyrate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

At ambient temperature a rapidly stirred solution of methyl 3-methyl-4-(2-methoxy-5-nitrophenoxy)butyrate(400 mg) in methanol (20 mL) containing 10% palladium on carbon (40 mg) was exposed to an atmosphere of hydrogen. When uptake of hydrogen had ceased the solution was filtered and the filter cake washed with methanol. The combined filtrates were evaporated to dryness under reduced pressure, to give methyl 3-methyl-4-(2-methoxy-5-aminophenoxy)butyrate as an oil. (317 mg) m/Z 254(M+H).

후처리

  1. filtrationwas filtered
  2. washthe filter cake washed with methanol
  3. customThe combined filtrates were evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-3f77f4683d644ee1a3028b3cc4762386
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06441012B1

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