Lactic Acid → beta-sitosterol Lactate

HRID 2306120

반응식

HRID 2306120 반응식
[CH3:1][CH2:2][C@@H:3]([CH:28]([CH3:30])[CH3:29])[CH2:4][CH2:5][C@H:6]([C@@H:8]1[C@@:12]2([CH3:27])[CH2:13][CH2:14][C@@H:15]3[C@@:20]4([CH3:26])[CH2:21][CH2:22][C@H:23]([OH:25])[CH2:24][C:19]4=[CH:18][CH2:17][C@H:16]3[C@@H:11]2[CH2:10][CH2:9]1)[CH3:7].[C:31]([OH:36])(=[O:35])[CH:32]([CH3:34])[OH:33].C1(C)C=CC=CC=1>O>[CH3:1][CH2:2][C@@H:3]([CH:28]([CH3:29])[CH3:30])[CH2:4][CH2:5][C@H:6]([C@@H:8]1[C@@:12]2([CH3:27])[CH2:13][CH2:14][C@@H:15]3[C@@:20]4([CH3:26])[CH2:21][CH2:22][C@H:23]([OH:25])[CH2:24][C:19]4=[CH:18][CH2:17][C@H:16]3[C@@H:11]2[CH2:10][CH2:9]1)[CH3:7].[C:31]([O-:36])(=[O:35])[CH:32]([CH3:34])[OH:33]

참가 물질

5

반응물 3

HCID 612Lactic AcidHCID 1140TolueneHCID 222284(-)-beta-Sitosterol

생성물 1

HCID 86758485beta-sitosterol Lactate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

200 g β-sitosterol, 250 g lactic acid, and 500 ml toluene were dissolved in a 5 l flask. The mixture was refluxed at 110-115° C. at the same time as water (free water+reaction water) was collected using water separation apparatus, in order to monitor the progress of the reaction. Reaction time was 11.5 h. At this point, 68 ml of water had been collected (free water: 33.8 ml+reaction water 34.2 ml), representing a 77.5% conversion in relation to the starting material. The toluene was evaporated from the reaction mixture using a rotavapor, and the product was dried in a vacuum oven at 40-60° C. The esterification experiment was repeated 5 times.

후처리

  1. customwas collected
  2. customwater separation apparatus
  3. customthe progress of the reaction
  4. customReaction time
  5. customAt this point, 68 ml of water had been collected
  6. custom(free water: 33.8 ml+reaction water 34.2 ml)
  7. customThe toluene was evaporated from the reaction mixture
  8. customthe product was dried in a vacuum oven at 40-60° C

출처 및 근거

ORD 기록
ord-fbea81868c184d6897ee545c557b3c4b
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06441206B1

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