2-Methoxy-8-nitroquinoline → 2-Methoxyquinolin-8-amine
반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([N+:13]([O-])=O)[CH:7]=[CH:8][CH:9]=2)[N:4]=1>CCO>[NH2:13][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:5]=1[N:4]=[C:3]([O:2][CH3:1])[CH:12]=[CH:11]2참가 물질
3
실험 절차
2-Methoxy-8-nitroquinoline, as described above in Step D, (2.07 g, 10.14 mmol) was dissolved in EtOH (150 mL) and EtOAc (150 mL), the vessel was degassed, Pd/C (200 mg, 10 wt %) was added and the vessel was filled with H2 (1 atm). After 1 hour, the reaction was filtered through a pad of celite and concentrated in vacuo. The residue was chromatographed on silica gel, eluting with CH2Cl2, to yield the above-titled compound.
후처리
- customEtOAc (150 mL), the vessel was degassed
- additionPd/C (200 mg, 10 wt %) was added
- additionthe vessel was filled with H2 (1 atm)
- filtrationthe reaction was filtered through a pad of celite
- concentrationconcentrated in vacuo
- customThe residue was chromatographed on silica gel
- washeluting with CH2Cl2
출처 및 근거
- ORD 기록
- ord-fe683297d3d141d5af1890da04c757d9
- 출처 데이터셋
- uspto-grants-2002_08
- 특허 번호
- US06441017B1
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