Benzenepropanoyl chloride → N-(3-phenylpropionyl)-D,L-alanine Isobutyl Ester

반응식

[C:1]1([CH2:7][CH2:8][C:9](Cl)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:13]([O:17][C:18](=[O:22])[CH:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[CH:19]([CH3:21])[NH:20][C:9](=[O:10])[CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH:14]([CH3:16])[CH3:15]

참가 물질

반응물 2

HCID 64801Benzenepropanoyl chloride

HCID 862001092-Methylpropyl 2-aminopropanoate hydrochloride

생성물 1

HCID 15480461N-(3-phenylpropionyl)-D,L-alanine Isobutyl Ester

실험 절차

Following General Procedure BA above and using 3-phenylpropionyl chloride (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of from 51°-54° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

후처리

customof from 51°-54° C
customThe reaction was monitored by tlc on silica gel and purification
extractionwas by extraction with Et2O

출처 및 근거

ORD 기록: ord-b4ada72309df474fa19249a38f0bf9b4
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06849650B2

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