Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Methanesulfonyloxy(4-methanesulfonyloxyphenyl)-acetic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | Benzeneacetic acid, alpha,4-dihydroxy-, ethyl ester | HCID 111357 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methanesulfonyloxy(4-methanesulfonyloxyphenyl)-acetic acid methyl ester | HCID 88018735 | — |
반응 단계
Methanesulfonyl chloride (0.395 ml, 5.10 mmol) is added dropwise at 0° C. to ethyl 4-hydroxymandelate (0.500 g, 2.55 mmol) and triethylamine (0.889 ml, 6.38 mmol) in DMF (5 ml) and the mixture is allowed to warm to room temperature overnight. The reaction mixture is diluted with water and extracted with ethyl acetate. The extract is washed with brine, dried (MgSO4), and evaporated to give oily residue which is purified by flash column chromatography (30% EtOAc/Hexane) (0.75 g, 82%). MS (m/z): [M+H]+=353.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06828317B2 |
| 출처 데이터셋 | uspto-grants-2004_12 |
| ORD ID | ord-0f02e586205a4cb9b87e93177351fb27 |
| 출처 메모 | uspto-grants-2004_12 |