1-(4-fluoro-benzyl)-1H-indazol-5-ylamine → (1-(4-Fluoro-benzyl)-1H-indazol-5-yl)-(6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine
반응식
[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([NH2:16])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[CH:4][CH:3]=1.Cl[C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([C:30]3[O:31][C:32]([C:35]([F:38])([F:37])[F:36])=[N:33][N:34]=3)[CH:28]=2)[N:23]=[CH:22][N:21]=1>>[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([NH:16][C:20]4[C:29]5[C:24](=[CH:25][CH:26]=[C:27]([C:30]6[O:31][C:32]([C:35]([F:38])([F:36])[F:37])=[N:33][N:34]=6)[CH:28]=5)[N:23]=[CH:22][N:21]=4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[CH:4][CH:3]=1참가 물질
3
실험 절차
The title compound was prepared according to Procedure A from 1-(4-fluoro-benzyl)-1H-indazol-5-ylamine and 4-chloro-6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazoline; δH [2H6]DMSO 11.91(1H, bs), 9.55(1H, s), 8.91(1H, s), 8.69(1H, dd), 8.23(1H, s), 8.14(2H, m), 7.88(1H, d), 7.69(1H, dd), 7.36(2H, m), 7.18 (2H, dd), 5.71(2H, s); m/z (M+1+) 506
출처 및 근거
- ORD 기록
- ord-a7d824afd5524ea6abd88e17138fd9a8