Dextrorphan hydrobromide → Dextrorphan

HRID 2306773노트

반응식

HRID 2306773 반응식
[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1.Br>C(#N)C.[N+]([O-])([O-])=O.[Ag+]>[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1

참가 물질

4

반응물 1

HCID 12309240Dextrorphan hydrobromide

생성물 1

HCID 5360697Dextrorphan

시약·촉매·용매 2

HCID 24470Silver Nitrate촉매HCID 6342Acetonitrile용매

실험 절차

The salt is prepared by adding silver nitrate (0.50 g, 2.96 mmoles) to a solution of Dextrorphan hydrobromide (1 g, 2.96 mmoles) in acetonitrile (17 ml). The solution is then stirred at room temperature for 30 minutes. Filtering is then effected to remove silver bromide precipitate. The clear solution is added of ethyl ether (100 ml). A precipitate is formed, that is filtered, washed with ethyl ether and dried under vacuum. The solid obtained at the elemental analysis corresponds to the nitrate salt of Dextrorphan:

후처리

  1. customThe salt is prepared
  2. filtrationFiltering
  3. customto remove silver bromide precipitate
  4. additionThe clear solution is added of ethyl ether (100 ml)
  5. customA precipitate is formed
  6. filtrationthat is filtered
  7. washwashed with ethyl ether
  8. customdried under vacuum

출처 및 근거

ORD 기록
ord-78e4adb3e5b44689835937dbff006ef4
출처 데이터셋
uspto-grants-2004_12
특허 번호
US06828342B2

반응 노트

불러오는 중…