Potassium Hydroxide → (3z)-2-[(Tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoic acid potassium salt

HRID 2306882노트

반응식

HRID 2306882 반응식
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:19])(/[CH:14]=[CH:15]\[CH2:16][C:17]#[N:18])[C:10]([O:12]C)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+:21]>O>[K+:21].[C:1]([O:5][C:6]([NH:8][C:9]([CH3:19])(/[CH:14]=[CH:15]\[CH2:16][C:17]#[N:18])[C:10]([O-:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 86585310Methyl (3Z)-2-[(tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoate

생성물 1

HCID 23689684(3z)-2-[(Tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoic acid potassium salt

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

The methyl (3Z)-2-[(tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoate product of Example 1d is taken up in DI water. To this is added KOH and the reaction mixture is stirred at 50° C. for 3 h. It is then concentrated under reduced pressure to give the desired title product.

후처리

  1. concentrationIt is then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a7c492f0292a424f947c1736dbaf5101
출처 데이터셋
uspto-grants-2004_12
특허 번호
US06828456B2

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