Ethanesulfonic acid → n-{2-Tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1h-benzimidazol-5-yl}ethanesulfonamide esylate

참여 물질

역할	이름	HCID	투입량
반응물	Ethanesulfonic acid	HCID 11668	—
반응물	Ethanesulfonamide, N-(1-((4,4-difluorocyclohexyl)methyl)-2-(1,1-dimethylethyl)-1H-benzimidazol-5-yl)-	HCID 11675994	—
용매	tert-Butyl methyl ether	HCID 15413	—
생성물	n-{2-Tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1h-benzimidazol-5-yl}ethanesulfonamide esylate	HCID 16742587	75%

반응 단계

N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide (111 mg) was slurried in methyl tert-butyl ether (2.1 ml) at 48° C. and ethane sulphonic acid (23 μl, 95%) was added. Shortly after the slurry became thinner and then recrystallised into a thicker slurry which was left over night at room temperature. The resulting crystals were filtered off, washed with methyl tert-butyl ether (2×400 μl) and dried at 40° C. under vacuum. A total of 105 mg (yield 75%) crystalline N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide esylate was obtained.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07566788B2
출처 데이터셋	uspto-grants-2009_07
ORD ID	ord-240d4f8e088747f9be62236267c2a75b
출처 메모	uspto-grants-2009_07