HCID 22176515, 화합물 → HCID 22176470, 화합물
반응식
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([CH2:11][CH3:12])[N+:3]=1[O-]>C(O)(=O)C.[Fe]>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH2:11][CH3:12])[N:3]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
A solution of 2-bromo-6-ethyl-4-nitro-pyridine 1-oxide (example 5b) (15.9 g, 69 mmol) in acetic acid (310 ml) was treated with powdered iron (25.8 g, 462 mmol). The mixture was slowly heated to 100° C. and kept for 1 hr at this temperature. Then the reaction mixture was cooled to rt and filtered. After evaporation of the solvent the residue was crystallized to yield the title compound as a beige material (88%). Mp. 75-77° C. (pentane), MS: m/e=200 (M+).
후처리
- temperatureThen the reaction mixture was cooled to rt
- filtrationfiltered
- customAfter evaporation of the solvent the residue
- customwas crystallized
출처 및 근거
- ORD 기록
- ord-a7269623d10b431a89cebff5584cc744
- 출처 데이터셋
- uspto-grants-2004_12
- 특허 번호
- US06831087B2
반응 노트
불러오는 중…