Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-[4-(3-Hydroxyphenyl)-2-thiophenyl]-1-propanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Bromo-2-propionylthiophene | HCID 818932 | — |
| 반응물 | (3-(Methoxymethoxy)phenyl)boronic acid | HCID 22606941 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-[4-(3-Hydroxyphenyl)-2-thiophenyl]-1-propanone | HCID 22606920 | — |
반응 단계
In a manner similar to that of Example 1(h), by reaction of 4.6 g (25 mmol) 3-methoxymethoxyphenylboronic acid (described in Example 1(g)) and 5 g (22.8 mmol) of 1-(4-bromo-2-thiophenyl)-1-propanone with 22.8 mL of 2.0M potassium carbonate and 1.32 g of tetrakis(triphenylphosphine)palladium, followed by deprotection in methanol, the desired product is obtained in the form of a white solid (m.p.=112° C.; m=3.87 g: Y=73%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06831106B1 |
| 출처 데이터셋 | uspto-grants-2004_12 |
| ORD ID | ord-a3dfd4a2b2664d89af009c56b11c1896 |
| 출처 메모 | uspto-grants-2004_12 |