Water → HCID 178526172, 화합물

HRID 230764

반응식

HRID 230764 반응식
[CH:1](O)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](O)(=O)[CH2:16][SH:17].[OH2:20]>FC(F)(F)C(O)=O>[CH:1]([CH2:15][C:16]([OH:20])=[S:17])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 1133Thioglycolic AcidHCID 7037Benzhydrol

생성물 1

HCID 178526172HCID 178526172, 화합물수율 99.3%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

To a solution of benzhydrol (100 g, 0.542 mol) in trifluoroacetic acid (300 mL) at room temperature (about 22 degrees C.) was added thioglycolic acid (50 g, 0.542 mol) drop wise over 20 minutes. Reaction progress was monitored by thin layer chromatography (TLC). The reaction was complete within one hour at which point water (1000 mL) was added slowly into the reaction mixture causing the product to precipitate. The resulting precipitate was filtered, washed with water and dried overnight under high vacuum to give benzhydrylthioacetic acid (139.3 g, 99.3%) as a pale yellow solid. (See Prisinzano, T. et al, Tetrahedron Asymm., 2004, 15, 1053-1058)

후처리

  1. customReaction progress
  2. additionwas added slowly into the reaction mixture
  3. customto precipitate
  4. filtrationThe resulting precipitate was filtered
  5. washwashed with water
  6. customdried overnight under high vacuum

출처 및 근거

ORD 기록
ord-09f72cf37365468fb9942dd777925bc3
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566805B2

연결된 노트

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