Hexane → Methyl 3-fluoropyridine-2-carboxylate

HRID 230775

반응식

HRID 230775 반응식
[CH3:1]CCCCC.C[Si](C=[N+]=[N-])(C)C.[F:14][C:15]1[C:16]([C:21]([OH:23])=[O:22])=[N:17][CH:18]=[CH:19][CH:20]=1>C(O)C.CN(C=O)C>[F:14][C:15]1[C:16]([C:21]([O:23][CH3:1])=[O:22])=[N:17][CH:18]=[CH:19][CH:20]=1

참가 물질

5

반응물 3

HCID 8058HexaneHCID 167693TrimethylsilyldiazomethaneHCID 27627863-Fluoropyridine-2-carboxylic acid

생성물 1

HCID 26746991Methyl 3-fluoropyridine-2-carboxylate

시약·촉매·용매 1

HCID 19794673N,N-dimethylformamide ethanol용매

실험 절차

A hexane solution (3 mL) of 2 M trimethylsilyldiazomethane was added to a benzene/methanol mixed solvent (1/1, 12 mL) of 3-fluoropyridine-2-carboxylic acid (250 mg), and stirred at room temperature for 30 minutes. The solvent was evaporated off under reduced pressure from the reaction solution, and the resulting residue was purified through silica gel column chromatography (chloroform/methanol=40/1) to obtain the entitled compound (238 mg).

후처리

  1. customThe solvent was evaporated off under reduced pressure from the reaction solution
  2. customthe resulting residue was purified through silica gel column chromatography (chloroform/methanol=40/1)

출처 및 근거

ORD 기록
ord-897de591f8e845dead7024a6fcef2167
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566781B2

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