Uracil → 1-Benzyloxycarbonylmethyl-2,4-dioxopyrimidine

HRID 2308182노트

반응식

HRID 2308182 반응식
CN(C)C=O.[O:6]=[C:7]1[NH:12][C:11](=[O:13])[CH:10]=[CH:9][NH:8]1.Br[CH2:15][C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17].C(=O)([O-])[O-].[K+].[K+]>O>[CH2:19]([O:18][C:16]([CH2:15][N:8]1[CH:9]=[CH:10][C:11](=[O:13])[NH:12][C:7]1=[O:6])=[O:17])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

6

반응물 4

HCID 1174UracilHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 62576Benzyl bromoacetate

생성물 1

HCID 226011191-Benzyloxycarbonylmethyl-2,4-dioxopyrimidine수율 60.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To anhydrous dimethylformamide solution (10 ml) containing 2,4-dioxopyrimidine (1.0 g) are added benzyl bromoacetate (2.5 g) and potassium carbonate (2.5 g), and the mixture is stirred at room temperature for 15 hours. The reaction solution is poured into water, and the mixture is extracted with ethyl acetate. The extract is washed with a saturated brine, and dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure, and the precipitated crystals are washed with diethyl ether to give the desired 1-benzyloxycarbonylmethyl-2,4-dioxopyrimidine (1.4 g) as colorless crystals.

후처리

  1. extractionthe mixture is extracted with ethyl acetate
  2. washThe extract is washed with a saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent is removed by evaporation under reduced pressure
  5. washthe precipitated crystals are washed with diethyl ether

출처 및 근거

ORD 기록
ord-ddd691a8b02340e7a32db9bdb3211bb4
출처 데이터셋
uspto-grants-2004_12
특허 번호
US06835714B1

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