Aniline → 3-(Phenylsulfamoyl)benzoic acid
반응식
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[C:15]1([NH:14][S:2]([C:5]2[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=2)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1참가 물질
4
실험 절차
3-Chlorosulfonyl-benzoic acid (300 mg, 1.36 mmol), and aniline (0.30 mL, 3.29 mmol) were stirred at room temperature in anhydrous CH2Cl2 (10 mL) overnight under N2. The reaction mixture was concentrated in vacuo. Purification of the residue on IR-120 ion exchange resin column (eluted with methanol) afforded the title compound (380 mg, 100%) as a white solid.
후처리
- concentrationThe reaction mixture was concentrated in vacuo
- customPurification of the residue
- washon IR-120 ion exchange resin column (eluted with methanol)
출처 및 근거
- ORD 기록
- ord-e4d6ccb5ae8a413991c3c0f0c0194871
- 출처 데이터셋
- uspto-grants-2004_12
- 특허 번호
- US06835731B2
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