3-Methoxyaniline → 6-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

HRID 230839노트

반응식

HRID 230839 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]([NH2:15])=[O:14].[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>C(O)C>[ClH:1].[I:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][C:3]([C:13]([NH2:15])=[O:14])=[C:2]2[NH:21][C:20]1[CH:22]=[CH:23][CH:24]=[C:18]([O:17][CH3:16])[CH:19]=1

참가 물질

4

반응물 2

HCID 108243-MethoxyanilineHCID 577632714-Chloro-6-iodoquinoline-3-carboxamide

생성물 1

HCID 674246056-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Intermediate 13 (5.0 g) was dissolved in ethanol (60 ml), 3-methoxyaniline (3.37 ml) (available from Aldrich) was added, and the mixture was heated under reflux for 2.5 h. The resulting precipitate was filtered off and washed with ether to give the title compound.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2.5 h
  3. filtrationThe resulting precipitate was filtered off
  4. washwashed with ether

출처 및 근거

ORD 기록
ord-37f88493502743c4a8b42cda0fa94fe9
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566786B2

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