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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 230848생성일: 2026년 10월 26일

N-(5-Chloro-3-methylidene-2,3-dihydro-1-benzofuran-4-yl)-2,2,2-trifluoroacetamide → 2,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamide

https://huagongshe.com/reaction/230848

반응식

참여 물질

역할이름HCID투입량
반응물N-(5-Chloro-3-methylidene-2,3-dihydro-1-benzofuran-4-yl)-2,2,2-trifluoroacetamideHCID 57763270—
촉매PalladiumHCID 23938—
용매EthanolHCID 702—
생성물2,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamideHCID 57763285104.2%

반응 단계

A solution of Intermediate 23 (0.10 g) in ethanol (20 ml) was added to 10% palladium on carbon (0.20 g) and the mixture stirred under an atmosphere of hydrogen for 20 h. The mixture was filtered through ‘hyflo’ filter aid, washed with ethanol and the solvent removed in vacuo to give the title compound as a white solid (0.092 g).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07566786B2
출처 데이터셋uspto-grants-2009_07
ORD IDord-07a50bda887847c5a08ffd5d164601dd
출처 메모uspto-grants-2009_07