4-Methoxy-alpha-toluenethiol → 4-{[3-(Methyloxy)phenyl]amino}-6-({[4-(methyloxy)phenyl]methyl}thio)-3-quinolinecarboxamide

HRID 230861노트

반응식

HRID 230861 반응식
Cl.I[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([NH2:15])=[O:14])=[C:6]2[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=1.CC(C)([O-])C.[K+].[CH3:31][O:32][C:33]1[CH:38]=[CH:37][C:36]([CH2:39][SH:40])=[CH:35][CH:34]=1.O(C1C=CC=CC=1P(C1C=CC=CC=1)C1C=CC=CC=1)C1C=CC=CC=1P(C1C=CC=CC=1)C1C=CC=CC=1>CN(C)C=O>[CH3:24][O:23][C:19]1[CH:18]=[C:17]([NH:16][C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([S:40][CH2:39][C:36]4[CH:37]=[CH:38][C:33]([O:32][CH3:31])=[CH:34][CH:35]=4)[CH:4]=3)[N:9]=[CH:8][C:7]=2[C:13]([NH2:15])=[O:14])[CH:22]=[CH:21][CH:20]=1

참가 물질

6

반응물 4

HCID 804074-Methoxy-alpha-toluenethiolHCID 4285986Bis[2-(diphenylphosphino)phenyl] etherHCID 23665647Potassium tert-butoxideHCID 674246056-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

생성물 1

HCID 577632404-{[3-(Methyloxy)phenyl]amino}-6-({[4-(methyloxy)phenyl]methyl}thio)-3-quinolinecarboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

Intermediate 14 (0.020 g), potassium tert-butoxide (0.0061 g) and [4-(methyloxy) phenyl]methanethiol (available from Aldrich) (0.007 ml) were added to a stirred solution of tris(dibenzylidineacetone)dipalladium(0) (0.002 g) and (oxydi-2,1-phenylene)bis (diphenylphosphine) (0.002 g) in N,N-dimethylformamide (1.5 ml), and the mixture was heated under microwave irradiation at 60° C. for 8 min. The solvent was evaporated in vacuo, and the residue purified by Mass Directed Preparative HPLC (Method A) to give the title compound (0.0048 g).

후처리

  1. customThe solvent was evaporated in vacuo
  2. customthe residue purified by Mass Directed Preparative HPLC (Method A)

출처 및 근거

ORD 기록
ord-28ee6ea5069f418aae92f3f69428b049
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566786B2

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