Piperazine → 8-Benzylthio-2-piperazino-4-thiomorpholino-pyrimido-[5,4-d]-pyrimidine

HRID 2308628노트

반응식

[CH2:1]([S:8][C:9]1[C:14]2[N:15]=[C:16](Cl)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH2:1]([S:8][C:9]1[C:14]2[N:15]=[C:16]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 4837Piperazine

HCID 130433708-Benzylthio-2-chloro-4-thiomorpholino-pyrimido[5,4-d]pyrimidine

생성물 1

HCID 201873578-Benzylthio-2-piperazino-4-thiomorpholino-pyrimido-[5,4-d]-pyrimidine

실험 절차

This compound was prepared analogous to Example 1 from 8-benzylthio-2-chloro-4-thiomorpholino-pyrimido-[5,4-d]-pyrimidine (m.p.: 162°-164° C.) and piperazine.

출처 및 근거

ORD 기록: ord-bb1a7646757c4989af256d808b242765
출처 데이터셋: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04690923

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