Methylamine → HCID 20186775, 화합물

HRID 2309008노트

반응식

HRID 2309008 반응식
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:16][CH2:17][CH:18]([O:26][CH2:27][CH2:28][OH:29])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=2)[CH3:15])=[CH:9][CH:8]=1)(OC)=[O:2].[CH3:30][NH2:31]>C(O)C>[ClH:25].[CH3:30][NH:31][C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:16][CH2:17][CH:18]([O:26][CH2:27][CH2:28][OH:29])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=2)[CH3:15])=[CH:9][CH:8]=1)=[O:2]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 21285459HCID 21285459, 화합물

생성물 1

HCID 20186775HCID 20186775, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-(2-hydroxyethoxy)-2-(3-chlorophenyl)ethanamine (4.0 g) and 33% methylamine in ethanol (50 ml) was heated under reflux for 1.5 h. The mixture was evaporated under reduced pressure and the residue converted to its hydrochloride by addition of ethereal hydrogen chloride. Recrystallisation from ethyl acetate-methanol gave the title compound, mp. 117°-121° C. as a 56:44 mixture of diastereoisomers.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 h
  3. customThe mixture was evaporated under reduced pressure
  4. additionthe residue converted to its hydrochloride by addition of ethereal hydrogen chloride
  5. customRecrystallisation from ethyl acetate-methanol

출처 및 근거

ORD 기록
ord-a3d7d059f30744e193bf503e17563581
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04692465

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