Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → 4-Chlorobenzyl-4-(3-chloropropyl)piperazine dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 4-Chlorobenzylpiperazine | HCID 134826 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Chlorobenzyl-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153189 | 146.8% |
반응 단계
First, 1-(4-chlorobenzyl)piperazine (20.0 g) is mixed with dimethyl sulfoxide (100 ml), potassium hydroxide (15.0 g) and 1-bromo-3-chloropropane (15.0 g) at room temperature for 3 hours. Water is added to the resulting solution, the reaction product is extracted with ether, dried (magnesium sulfate), and the salt is precipitated with ethereal hydrochloric acid to yield 25.1 g of 1-(4-chlorobenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04692448 |
| 출처 데이터셋 | uspto-grants-1987_09 |
| ORD ID | ord-b4925db61d2e4b03a8789b505bcdf994 |
| 출처 메모 | uspto-grants-1987_09 |