Sulfuric Acid → 1-Methylethyl 2-hydroxy-5-(1-oxooctadecyl)benzoate

HRID 2309147노트

반응식

HRID 2309147 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11](=[O:29])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH:35](O)([CH3:37])[CH3:36]>>[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11](=[O:29])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:7][C:3]=1[C:4]([O:6][CH:35]([CH3:37])[CH3:36])=[O:5]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 51009112-Hydroxy-5-(1-oxooctadecyl)benzoic acid

생성물 1

HCID 133934571-Methylethyl 2-hydroxy-5-(1-oxooctadecyl)benzoate

실험 절차

A solution of the title product of Example 4 (6.2 mmole) and sulfuric acid (0.5 ml) in 120 ml of isopropyl alcohol (100 ml) was heated at 45° C. for 12 days, refluxed for 36 hours, and concentrated on a rotary evaporator to an oil. The oil was dissolved in methylene chloride, washed with water, dried over sodium sulfate, filtered, and concentrated under vacuum to give the title compound, m.p. 72°-73° C.

후처리

  1. temperaturerefluxed for 36 hours
  2. concentrationconcentrated on a rotary evaporator to an oil
  3. dissolutionThe oil was dissolved in methylene chloride
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-cdd273367a164bb49b96553940804b75
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04692552

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