Bacitracin → HCID 86741792, 화합물

HRID 2309220

반응식

HRID 2309220 반응식
[Co:1].[CH3:2][CH2:3][C@@H:4]([C:25]([C@H:27]([C@@H:29]([OH:45])[C@H:30]([C@H:32]1[O:37][C@@H:36]([CH2:38][C:39]([O:41][OH:42])=[O:40])[C@H:35]([CH3:43])[CH2:34][C@@H:33]1[CH3:44])[CH3:31])[CH3:28])=[O:26])[C@H:5]1[O:9][C@@:8]([C@:11]2([OH:23])[O:15][C@@:14]([C@@H:18]([OH:21])[CH2:19][CH3:20])([CH2:16][CH3:17])[CH2:13][C@H:12]2[CH3:22])([CH3:10])[CH2:7][C@@H:6]1[CH3:24].[CH3:46][CH2:47][C@@H:48]([C@@H:50]1[NH:81][C:79](=[O:80])[C@@H:78]([CH2:82][CH2:83][CH2:84][NH2:85])[NH:77][C:75](=[O:76])[C@@H:74]([NH:86][C:87]([C@@H:89]([NH:94][C:95]([C@H:97]([NH:103][C:104]([C@@H:106]([NH:111][C:112]([C@H:114]2[N:118]=[C:117]([C@@H:119]([NH2:124])[C@H:120]([CH2:122][CH3:123])[CH3:121])[S:116][CH2:115]2)=[O:113])[CH2:107][CH:108]([CH3:110])[CH3:109])=[O:105])[CH2:98][CH2:99][C:100]([OH:102])=[O:101])=[O:96])[C@H:90]([CH2:92][CH3:93])[CH3:91])=[O:88])[CH2:73][CH2:72][CH2:71][CH2:70][NH:69][C:67](=[O:68])[C@H:66]([CH2:125][C:126]([NH2:128])=[O:127])[NH:65][C:63](=[O:64])[C@@H:62]([CH2:129][C:130]([OH:132])=[O:131])[NH:61][C:59](=[O:60])[C@H:58]([CH2:133][C:134]2[NH:138][CH:137]=[N:136][CH:135]=2)[NH:57][C:55](=[O:56])[C@@H:54]([CH2:139][C:140]2[CH:141]=[CH:142][CH:143]=[CH:144][CH:145]=2)[NH:53][C:51]1=[O:52])[CH3:49]>CO>[CH3:46][CH2:47][C@@H:48]([C@@H:50]1[NH:81][C:79](=[O:80])[C@@H:78]([CH2:82][CH2:83][CH2:84][NH2:85])[NH:77][C:75](=[O:76])[C@@H:74]([NH:86][C:87]([C@@H:89]([NH:94][C:95]([C@H:97]([NH:103][C:104]([C@@H:106]([NH:111][C:112]([C@H:114]2[N:118]=[C:117]([C@@H:119]([NH2:124])[C@H:120]([CH2:122][CH3:123])[CH3:121])[S:116][CH2:115]2)=[O:113])[CH2:107][CH:108]([CH3:109])[CH3:110])=[O:105])[CH2:98][CH2:99][C:100]([OH:102])=[O:101])=[O:96])[C@H:90]([CH2:92][CH3:93])[CH3:91])=[O:88])[CH2:73][CH2:72][CH2:71][CH2:70][NH:69][C:67](=[O:68])[C@H:66]([CH2:125][C:126]([NH2:128])=[O:127])[NH:65][C:63](=[O:64])[C@@H:62]([CH2:129][C:130]([OH:132])=[O:131])[NH:61][C:59](=[O:60])[C@H:58]([CH2:133][C:134]2[NH:138][CH:137]=[N:136][CH:135]=2)[NH:57][C:55](=[O:56])[C@@H:54]([CH2:139][C:140]2[CH:141]=[CH:142][CH:143]=[CH:144][CH:145]=2)[NH:53][C:51]1=[O:52])[CH3:49].[Co:1].[CH3:2][CH2:3][C@@H:4]([C:25]([C@H:27]([C@@H:29]([OH:45])[C@H:30]([C@H:32]1[O:37][C@@H:36]([CH2:38][C:39]([O:41][OH:42])=[O:40])[C@H:35]([CH3:43])[CH2:34][C@@H:33]1[CH3:44])[CH3:31])[CH3:28])=[O:26])[C@H:5]1[O:9][C@@:8]([C@:11]2([OH:23])[O:15][C@@:14]([C@@H:18]([OH:21])[CH2:19][CH3:20])([CH2:16][CH3:17])[CH2:13][C@H:12]2[CH3:22])([CH3:10])[CH2:7][C@@H:6]1[CH3:24]

참가 물질

4

반응물 2

HCID 10909430Bacitracin2회HCID 86741793Cobalt lysocellin

생성물 1

HCID 86741792HCID 86741792, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1.3 grams (g) of cobalt lysocellin prepared as described in Example A, in 25 ml of methanol was stirred while 1.5 g of regular (reg) bacitracin (reg) was added thereto. Stirring was continued until solution of the bacitracin was complete. The reaction mixture was agitated at room temperature until precipitation of the complex occurred. The complex was isolated and recrystallized from methanol (10 ml/g) to obtain rod-like crystals.

후처리

  1. additionwas added
  2. stirringThe reaction mixture was agitated at room temperature until precipitation of the complex
  3. customThe complex was isolated
  4. customrecrystallized from methanol (10 ml/g)
  5. customto obtain rod-like crystals

출처 및 근거

ORD 기록
ord-7568240176ab4fe9a41c79c6ecb477d4
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04693992

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