Bacitracin → Bacitracin Sodium Lysocellin

HRID 2309223

반응식

HRID 2309223 반응식
[Na:1].[CH3:2][CH2:3][C@@H:4]([C:25]([C@H:27]([C@@H:29]([OH:45])[C@H:30]([C@H:32]1[O:37][C@@H:36]([CH2:38][C:39]([O:41][OH:42])=[O:40])[C@H:35]([CH3:43])[CH2:34][C@@H:33]1[CH3:44])[CH3:31])[CH3:28])=[O:26])[C@H:5]1[O:9][C@@:8]([C@:11]2([OH:23])[O:15][C@@:14]([C@@H:18]([OH:21])[CH2:19][CH3:20])([CH2:16][CH3:17])[CH2:13][C@H:12]2[CH3:22])([CH3:10])[CH2:7][C@@H:6]1[CH3:24].[CH3:46][CH2:47][C@@H:48]([C@@H:50]1[NH:81][C:79](=[O:80])[C@@H:78]([CH2:82][CH2:83][CH2:84][NH2:85])[NH:77][C:75](=[O:76])[C@@H:74]([NH:86][C:87]([C@@H:89]([NH:94][C:95]([C@H:97]([NH:103][C:104]([C@@H:106]([NH:111][C:112]([C@H:114]2[N:118]=[C:117]([C@@H:119]([NH2:124])[C@H:120]([CH2:122][CH3:123])[CH3:121])[S:116][CH2:115]2)=[O:113])[CH2:107][CH:108]([CH3:110])[CH3:109])=[O:105])[CH2:98][CH2:99][C:100]([OH:102])=[O:101])=[O:96])[C@H:90]([CH2:92][CH3:93])[CH3:91])=[O:88])[CH2:73][CH2:72][CH2:71][CH2:70][NH:69][C:67](=[O:68])[C@H:66]([CH2:125][C:126]([NH2:128])=[O:127])[NH:65][C:63](=[O:64])[C@@H:62]([CH2:129][C:130]([OH:132])=[O:131])[NH:61][C:59](=[O:60])[C@H:58]([CH2:133][C:134]2[NH:138][CH:137]=[N:136][CH:135]=2)[NH:57][C:55](=[O:56])[C@@H:54]([CH2:139][C:140]2[CH:141]=[CH:142][CH:143]=[CH:144][CH:145]=2)[NH:53][C:51]1=[O:52])[CH3:49]>CO>[CH3:46][CH2:47][C@@H:48]([C@@H:50]1[NH:81][C:79](=[O:80])[C@@H:78]([CH2:82][CH2:83][CH2:84][NH2:85])[NH:77][C:75](=[O:76])[C@@H:74]([NH:86][C:87]([C@@H:89]([NH:94][C:95]([C@H:97]([NH:103][C:104]([C@@H:106]([NH:111][C:112]([C@H:114]2[N:118]=[C:117]([C@@H:119]([NH2:124])[C@H:120]([CH2:122][CH3:123])[CH3:121])[S:116][CH2:115]2)=[O:113])[CH2:107][CH:108]([CH3:109])[CH3:110])=[O:105])[CH2:98][CH2:99][C:100]([OH:102])=[O:101])=[O:96])[C@H:90]([CH2:92][CH3:93])[CH3:91])=[O:88])[CH2:73][CH2:72][CH2:71][CH2:70][NH:69][C:67](=[O:68])[C@H:66]([CH2:125][C:126]([NH2:128])=[O:127])[NH:65][C:63](=[O:64])[C@@H:62]([CH2:129][C:130]([OH:132])=[O:131])[NH:61][C:59](=[O:60])[C@H:58]([CH2:133][C:134]2[NH:138][CH:137]=[N:136][CH:135]=2)[NH:57][C:55](=[O:56])[C@@H:54]([CH2:139][C:140]2[CH:141]=[CH:142][CH:143]=[CH:144][CH:145]=2)[NH:53][C:51]1=[O:52])[CH3:49].[Na:1].[CH3:2][CH2:3][C@@H:4]([C:25]([C@H:27]([C@@H:29]([OH:45])[C@H:30]([C@H:32]1[O:37][C@@H:36]([CH2:38][C:39]([O:41][OH:42])=[O:40])[C@H:35]([CH3:43])[CH2:34][C@@H:33]1[CH3:44])[CH3:31])[CH3:28])=[O:26])[C@H:5]1[O:9][C@@:8]([C@:11]2([OH:23])[O:15][C@@:14]([C@@H:18]([OH:21])[CH2:19][CH3:20])([CH2:16][CH3:17])[CH2:13][C@H:12]2[CH3:22])([CH3:10])[CH2:7][C@@H:6]1[CH3:24]

참가 물질

4

반응물 2

HCID 10909430BacitracinHCID 86741790Sodium lysocellin

생성물 1

HCID 86741797Bacitracin Sodium Lysocellin수율 89.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 13.0 g sodium lysocellin in 300 ml of methanol was stirred while 28.0 g bacitracin (reg) was added. Stirring was continued until solution of solids was complete. The resulting solution was held at room temperature for 18 hours. A precipitate formed and was collected on a filter, rinsed with methanol and dried to give 36.5 g of an amorphous product.

후처리

  1. additionwas added
  2. customA precipitate formed
  3. customwas collected on a filter
  4. washrinsed with methanol
  5. customdried

출처 및 근거

ORD 기록
ord-768c058b0a164c88912dc195a1014ae8
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04693992

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