Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorobenzoyl chloride → 2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorobenzoyl chloride | HCID 8501 | — |
| 반응물 | D-Tryptophan | HCID 9060 | — |
| 생성물 | 2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid | HCID 2787526 | 74.5% |
반응 단계
By using 10 g of D-tryptophane and 9 g of 4-chlorobenzoyl chloride, and a method similar to that described in reference Example 6, recrystallized from methanol-water, there was obtained 12.5 g of 2-(4-chlorobenzoylamino)-3-(indol-3-yl)propionic acid. Colorless needle-like crystals. Melting point: 100°-102° C. [α]D20 +51.5° (C=1, methanol)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04694017 |
| 출처 데이터셋 | uspto-grants-1987_09 |
| ORD ID | ord-5fbb4fe6c0ce401e867bd68064d97d00 |
| 출처 메모 | uspto-grants-1987_09 |