4-Fluorophenyl isocyanate → HCID 13603335, 화합물

반응식

[CH3:1][CH:2]1[O:16][C:5]2=[CH:6][C:7]3[CH2:8][C:9](=[O:15])[N:10]([CH2:13][CH3:14])[C:11]=3[CH:12]=[C:4]2[CH2:3]1.[F:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25]([CH:8]2[C:7]3[CH:6]=[C:5]4[O:16][CH:2]([CH3:1])[CH2:3][C:4]4=[CH:12][C:11]=3[N:10]([CH2:13][CH3:14])[C:9]2=[O:15])=[O:26])=[CH:20][CH:19]=1

참가 물질

반응물 2

HCID 709554-Fluorophenyl isocyanate

HCID 20185127HCID 20185127, 화합물

생성물 1

HCID 13603335HCID 13603335, 화합물수율 45%

실험 절차

Following the procedure of Example 1 and employing 326 mg. (1.5 mmoles) of 2-methyl-5-ethyl-6-oxo-2,3,6,7-tetrahydrofuro[2,3-f]indole and 0.24 ml. (2.1 mmoles) of 4-fluorophenylisocyanate, 240 mg. (45% yield), m.p. 196°-197° C. of the desired product was obtained.

출처 및 근거

ORD 기록: ord-68dd89360824420cb5faf3df37464429
출처 데이터셋: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04695571

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