Potassium Carbonate → HCID 70353795, 화합물
반응식
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]([OH:26])=[C:9]([CH2:12][CH2:13][CH2:14]OS(C3C=CC(C)=CC=3)(=O)=O)[CH:10]=2)[CH2:5][C:4]1=[O:27])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]3[O:26][CH2:14][CH:13]=[CH:12][C:9]=3[CH:10]=2)[CH2:5][C:4]1=[O:27])[CH3:2]참가 물질
4
실험 절차
A mixture of 1.65 g. (4.41 mmoles) of 1-ethyl-5-hydroxy-6-(3-tosyloxypropyl)oxindole and 610 mg. (4.41 mmoles) of potassium carbonate in 90 ml. of acetone was heated at reflux for 2.5 hours. The reaction was cooled, filtered and the filtrate evaporated. The crude residue was purified by chromatographing on 100 g. of silica gel, using 66% diethyl ether-hexane as the eluent, to give 571 mg. (60% yield) of the desired intermediate.
후처리
- additionA mixture of 1.65 g
- temperatureat reflux for 2.5 hours
- temperatureThe reaction was cooled
- filtrationfiltered
- customthe filtrate evaporated
- customThe crude residue was purified by chromatographing on 100 g
- customto give 571 mg
출처 및 근거
- ORD 기록
- ord-ddd2db1f5bb24722a2cbff509446ce72
- 출처 데이터셋
- uspto-grants-1987_09
- 특허 번호
- US04695571
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