Phenylacetic Acid → 2-(phenylacetamido)butyric Acid Iso-butyl Ester

반응식

[C:1]1([CH2:7][C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][CH:12]([CH2:20][CH3:21])[C:13]([O:15][CH2:16][CH:17]([CH3:19])[CH3:18])=[O:14]>>[CH2:16]([O:15][C:13](=[O:14])[CH:12]([NH:11][C:8](=[O:10])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH2:20][CH3:21])[CH:17]([CH3:18])[CH3:19]

참가 물질

반응물 2

HCID 999Phenylacetic Acid

HCID 13743360Isobutyl 2-aminobutyrate

생성물 1

HCID 541767772-(phenylacetamido)butyric Acid Iso-butyl Ester

실험 절차

Following General Procedure BH above and using phenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above) the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by chromatography on silica gel using 9:1 toluene: EtOAc as the eluant.

출처 및 근거

ORD 기록: ord-01993111ebdf4eef835a7c3166fdf998
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06849650B2

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