Einecs 211-027-4 → 2,6-Dimethyl-4-(3-methyl-1H-indol-2-yl)phenol

HRID 2309404노트

반응식

HRID 2309404 반응식
C[O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([C:10]2[NH:11][C:12]3[C:17]([C:18]=2[CH3:19])=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:5][C:4]=1[CH3:20].[Cl-].[NH+]1C=CC=CC=1>O>[OH:2][C:3]1[C:4]([CH3:20])=[CH:5][C:6]([C:10]2[NH:11][C:12]3[C:17]([C:18]=2[CH3:19])=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:7][C:8]=1[CH3:9]

참가 물질

4

반응물 2

HCID 69401Einecs 211-027-4HCID 136701412-(4-Methoxy-3,5-dimethylphenyl)-3-methylindole

생성물 1

HCID 136701422,6-Dimethyl-4-(3-methyl-1H-indol-2-yl)phenol수율 63.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4.3 g of 2-(4-methoxy-3,5-dimethylphenyl)-3-methylindole and 13 g of pyridinium chloride were reacted at 200° C. for 1.5 hours. The reaction mixture was cooled, poured into water, extracted with ethyl acetate, washed with water, and dried. The solvent was evaporated, and the residue was recrystallized from benzene-hexane to give 2.6 g of 2-(4-hydroxy-3,5-dimethylphenyl)-3-methylindole.

후처리

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with ethyl acetate
  3. washwashed with water
  4. customdried
  5. customThe solvent was evaporated
  6. customthe residue was recrystallized from benzene-hexane

출처 및 근거

ORD 기록
ord-b3a29044874c44b495ff169bdfa34147
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04695581

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