Ethyl 3-amino-3-methylbutanoate → Ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate

HRID 2309678노트

반응식

HRID 2309678 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]=[C:7]=[O:8].[NH2:9][C:10]([CH3:18])([CH3:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]>C(Cl)Cl>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([NH:9][C:10]([CH3:18])([CH3:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[O:8]

참가 물질

4

반응물 2

HCID 11480520Ethyl 3-amino-3-methylbutanoateHCID 149715841-Bromo-4-isocyanatobutane

생성물 1

HCID 20184474Ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate수율 95%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
-20 °C

실험 절차

A solution of 4-bromobutylisocyanate (15.1 g) in methylene chloride (50 ml) is added to a stirred solution of ethyl 3-amino-3-methylbutanoate (12.3 g), dissolved in methylene chloride (50 ml) at -20° C. The mixture is stirred for 30 minutes at -20° C. and then for an additional 2 hours at room temperature. Evaporation of the solvent yields a residue of ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate (26 g).

후처리

  1. waitfor an additional 2 hours at room temperature
  2. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-d021e12515424ff3a33414c07576d365
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04696927

반응 노트

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