Acetic acid, 2-(4-formylphenoxy)- → Pyrimidin-2,4-dione, 6-amino-5-[(4-carboxymethoxy)benzimidoyl]-1,3-dipr

HRID 2309704

반응식

HRID 2309704 반응식
[C:1]([CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=1)([OH:3])=[O:2].[NH2:14][C:15]1[C:16](=[O:29])[N:17]([CH2:26][CH2:27][CH3:28])[C:18](=[O:25])[N:19]([CH2:22][CH2:23][CH3:24])[C:20]=1[NH2:21]>CO.C(O)(=O)C>[NH2:21][C:20]1[N:19]([CH2:22][CH2:23][CH3:24])[C:18](=[O:25])[N:17]([CH2:26][CH2:27][CH3:28])[C:16](=[O:29])[C:15]=1[N:14]=[CH:10][C:9]1[CH:12]=[CH:13][C:6]([O:5][CH2:4][C:1]([OH:3])=[O:2])=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 89177Acetic acid, 2-(4-formylphenoxy)-HCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 614654Pyrimidin-2,4-dione, 6-amino-5-[(4-carboxymethoxy)benzimidoyl]-1,3-dipr

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 887Methanol용매

실험 절차

A representative synthesis of benzylidene adduct is given. Compound A (1.51 g, 8.37 mmol) was dissolved in a mixture of methanol (35 ml) and acetic acid (5 ml) in a 50 ml boiling flask on a steam bath. To this was added a methanolic solution (60 ml) of freshly synthesized 5,6-diamino-1,3-dipropyluracil. After heating 15 minutes, the volume was reduced by evaporation until crystallization occurred. Ether (40 ml) was added and the nearly white solid was collected. Yield 2.80 g (86%), mp 179°-180° C. Analysis (C19H24N4O5): calc. 58.60% C, 6.21% H, 14.39% N; found 58.72% C, 6.16% H, 14.43% N.

후처리

  1. customA representative synthesis of benzylidene adduct
  2. temperatureAfter heating 15 minutes
  3. customthe volume was reduced by evaporation until crystallization
  4. additionEther (40 ml) was added
  5. customthe nearly white solid was collected

출처 및 근거

ORD 기록
ord-1af5a30a224245769645271e64da0b4c
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04696932

연결된 노트

불러오는 중…