Water → 3,6-Dihydroxy-4,5-dimethylacridine

HRID 2309730

반응식

HRID 2309730 반응식
[OH:1]C1C=CC2C(C=1)=NC1C(=CC=C(O)C=1)C=2.NC1C=CC2C(C=1)=NC1C(=CC=C(N)C=1)C=2.N[C:34]1[CH:35]=[CH:36][C:37]2[C:46]([C:47]=1[CH3:48])=[N:45][C:44]1[C:39](=[CH:40][CH:41]=[C:42](N)[C:43]=1[CH3:49])[CH:38]=2.S(=O)(=O)(O)O.[OH2:56]>>[OH:56][C:34]1[CH:35]=[CH:36][C:37]2[C:46]([C:47]=1[CH3:48])=[N:45][C:44]1[C:39](=[CH:40][CH:41]=[C:42]([OH:1])[C:43]=1[CH3:49])[CH:38]=2

참가 물질

6

반응물 5

HCID 962Water2회HCID 1118Sulfuric AcidHCID 7099ProflavineHCID 38518Acridine, 3,6-diamino-4,5-dimethyl-HCID 135482596Acridine-3,6-diol

생성물 1

HCID 1358383693,6-Dihydroxy-4,5-dimethylacridine

실험 절차

3,6-Dihydroxy-4,5-dimethylacridine is prepared by the procedure of Benda, L., Ber., 45, 1787 (1912), for the preparation of 3,6-dihydroxyacridine from 3,6-diaminoacridine. In this reaction 3,6-diamino-4,5-dimethylacridine is heated in a bomb with two parts of water and one part concentrated sulfuric acid at 200° C. for 8 hours. The reaction mixture is diluted with water and the crude solid collected by filtration. This material is purified by dissolution in excess 1N sodium hydroxide, followed by treatment with charcoal and then acidification with acetic acid, giving an orange solid.

후처리

  1. filtrationthe crude solid collected by filtration
  2. customThis material is purified by dissolution in excess 1N sodium hydroxide
  3. customacidification with acetic acid, giving an orange solid

출처 및 근거

ORD 기록
ord-554ba3a361f4426ca723c67c867b6c1c
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04696936

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