Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Permanganate → 1-Phenyl-1-[4-(4-pyridyl)-2-thiazolyl]methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Permanganate | HCID 516875 | — |
| 반응물 | 4-(2-Benzyl-1,3-thiazol-4-yl)pyridine | HCID 14096952 | — |
| 촉매 | Tetrahexylammonium iodide | HCID 75056 | — |
| 용매 | Benzene | HCID 241 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-Phenyl-1-[4-(4-pyridyl)-2-thiazolyl]methanone | HCID 14096958 | 18.8% |
반응 단계
To a mixture of 2-benzyl-4-(4-pyridyl)thiazole (3.00 g, 0.01 mol) and potassium permanganate (3.16 g, 0.02 mol) in benzene (30 mL) and water (60 mL) was added tetrahexyl ammonium iodide (0.96 g, 0.02 mol). The biphasic mixture was heated at reflux for 15 hours. After cooling the organic layer was separated and concentrated. The residue was taken up in ethyl acetate, filtered through silica gel, concentrated and chromatographed (ethyl acetate/hexane as eluant). Recrystallization from ethyl acetate/hexane afforded 1-phenyl-1-[4-(4-pyridyl)-2-thiazolyl]methanone (0.50 g, 11%). mp. 135°-136° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04697012 |
| 출처 데이터셋 | uspto-grants-1987_09 |
| ORD ID | ord-1cb6fdebe7074db480a459f0c84a1e37 |
| 출처 메모 | uspto-grants-1987_09 |