Ethanol → Ethyl 3-methoxy-4-(7H-purin-8-yl)benzoate

반응식

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9](N)=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1.[CH2:21]([OH:23])[CH3:22]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([O:23][CH2:21][CH3:22])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1

참가 물질

반응물 2

HCID 702Ethanol

HCID 132845313-Methoxy-4-(7H-purin-8-yl)benzamide

생성물 1

HCID 13284533Ethyl 3-methoxy-4-(7H-purin-8-yl)benzoate

실험 절차

A quantity of 0.42 gm of 8-(2'-methoxy-4'-chlorocarbonyl-phenyl)-purine hydrochloride (see Example 43) was refluxed in 30 ml of ethanol for 45 minutes. The solvent was evaporated off, and the residue was purified over a silica gel column [eluant:methylene chloride/ethanol (50:1 to 19:1)].

후처리

customThe solvent was evaporated off
customthe residue was purified over a silica gel column [eluant:methylene chloride/ethanol (50:1 to 19:1)]

출처 및 근거

ORD 기록: ord-521ed348f7fd4b9b9dd5bdd736d478ae
출처 데이터셋: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04696931

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