Dimethylamine → 2-(2'-Methoxy-4'-dimethylaminosulfonyl-phenyl)-imidazo[4,5-b]pyridine hydrochloride

HRID 2309884노트

반응식

HRID 2309884 반응식
Cl.[CH3:2][O:3][C:4]1[CH:9]=[C:8]([S:10]([Cl:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:5]=1[C:14]1[NH:15][C:16]2[C:17]([N:22]=1)=[N:18][CH:19]=[CH:20][CH:21]=2.COC1C=C(S(Cl)(=O)=O)C=CC=1C(O)=O.[CH3:38][NH:39][CH3:40]>>[ClH:13].[CH3:2][O:3][C:4]1[CH:9]=[C:8]([S:10]([N:39]([CH3:40])[CH3:38])(=[O:12])=[O:11])[CH:7]=[CH:6][C:5]=1[C:14]1[NH:15][C:16]2[C:17]([N:22]=1)=[N:18][CH:19]=[CH:20][CH:21]=2

참가 물질

4

반응물 3

HCID 674DimethylamineHCID 201845172-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-imidazo[4,5-b]pyridine hydrochlorideHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

생성물 1

HCID 201845662-(2'-Methoxy-4'-dimethylaminosulfonyl-phenyl)-imidazo[4,5-b]pyridine hydrochloride

실험 절차

The crude 2-(2'-methoxy-4'-chlorosulfonyl-phenyl)-imidazo[4,5-b]pyridine hydrochloride prepared from 2.5 gm of 2-methoxy-4-chlorosulfonyl-benzoic acid according to Example C was added to 150 ml of a saturated aqueous dimethylamine solution at 10° C., under stirring, and a light-colored precipitate formed slowly. After stirring for 20 hours at ambient temperature, 200 ml of ice water were added. The precipitate was dried and then taken up in 60 ml of methanol, and 10 ml of methanolic hydrochloric acid were added. After filtering over active charcoal, the solvent was eliminated, and the residue remaining was digested with acetone and ether, subjected to suction filtration, and washed with ether.

후처리

  1. customa light-colored precipitate formed slowly
  2. stirringAfter stirring for 20 hours at ambient temperature
  3. customThe precipitate was dried
  4. addition10 ml of methanolic hydrochloric acid were added
  5. filtrationAfter filtering over active charcoal
  6. filtrationsubjected to suction filtration
  7. washwashed with ether

출처 및 근거

ORD 기록
ord-b0531ecf3c564a98af57cd6405a0dd48
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04696931

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