Sulfuric Acid → 5-Aminocarbonyl-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)benzimidazole

HRID 2309913노트

반응식

HRID 2309913 반응식
[C:1]([C:3]1[CH:24]=[CH:23][C:6]2[N:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][C:11]=3[O:21][CH3:22])[NH:9][C:5]=2[CH:4]=1)#[N:2].S(=O)(=O)(O)[OH:26]>>[NH2:2][C:1]([C:3]1[CH:24]=[CH:23][C:6]2[N:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([O:16][S:17]([CH3:20])(=[O:18])=[O:19])=[CH:12][C:11]=3[O:21][CH3:22])[NH:9][C:5]=2[CH:4]=1)=[O:26]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 201845285-Cyano-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole

생성물 1

HCID 201845645-Aminocarbonyl-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)benzimidazole

실험 절차

One gram (2.91 mmol) of 5-cyano-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole was added batchwise to 15 ml of concentrated sulfuric acid, and the resulting mixture was stirred for 24 hours at ambient temperature. The solution was then poured onto 300 ml of ice water, and the product precipitated was subjected to suction filtration and recrystallized from methanol.

후처리

  1. customthe product precipitated
  2. filtrationwas subjected to suction filtration
  3. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-6acd20d33d334a2283b6bd807ca0b218
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04696931

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