Ibuprofen, (+-)- → Ibuprofen codeine

반응식

[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.[OH:23][C:24]([CH:26]([C:28]1[CH:37]=[CH:36][C:31]([CH2:32][CH:33]([CH3:35])[CH3:34])=[CH:30][CH:29]=1)[CH3:27])=[O:25]>>[OH:25][C:24]([CH:26]([C:28]1[CH:29]=[CH:30][C:31]([CH2:32][CH:33]([CH3:34])[CH3:35])=[CH:36][CH:37]=1)[CH3:27])=[O:23].[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1

참가 물질

반응물 2

HCID 3672Ibuprofen, (+-)-

HCID 5284371Codeine

생성물 1

HCID 9849057Ibuprofen codeine

실험 절차

Codeine Phosphate, microcrystalline cellulose (Avicel PH102) and Starch 1500 were dry mixed. An aqueous solution of polyvinylpyrrolidone was then added to the dry powder and the mixture was granulated to give codeine granules. Microcrystalline cellulose (Avicel PH101) was then mixed with the granules. Finally, the codeine and ibuprofen granules were compressed to give an ibuprofen-codeine bilayer tablet with a crushing strength of 11-12 kp.

출처 및 근거

ORD 기록: ord-59bd06f1bc794c6582feaf1dc95b8d04
출처 데이터셋: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04844907

반응 노트

불러오는 중…