4-Hydroxybenzoic Acid → 4-(1-Methylheptyloxycarbonyl)phenol

HRID 231025

반응식

HRID 231025 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][C@@H:12](O)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].S(=O)(=O)(O)O>C1C=CC=CC=1>[CH3:11][CH:12]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[CH:3][CH:4]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

5

반응물 3

HCID 1354-Hydroxybenzoic AcidHCID 1118Sulfuric AcidHCID 80080(R)-2-Octanol

생성물 1

HCID 110103794-(1-Methylheptyloxycarbonyl)phenol수율 43%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

27.6 g of p-hydroxybenzoic acid and 39.0 g of (R)-2-octanol were refluxed for 10 hours in 300 ml of benzene in the presence of 0.5 ml of conc. sulfuric acid. Then, the reaction solution was cooled to the room temperature, and then concentrated and purified by column chromatography, to obtain 21.5 g of p-hydroxybenzoic acid 1-methylheptyl ester. (yield: 43%)

후처리

  1. concentrationconcentrated
  2. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-9a63337d10b54f90af339903302db2f4
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04844835

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