p-Tolylacetic acid → N-[(4-methylphenyl)acetyl]alanine iso-butyl ester

반응식

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=1)[CH:13]([CH3:15])[CH3:14]

참가 물질

반응물 2

HCID 248474p-Tolylacetic acid

HCID 137435562-methylpropyl (2S)-2-aminopropanoate

생성물 1

HCID 53936136N-[(4-methylphenyl)acetyl]alanine iso-butyl ester

실험 절차

Following General Procedure BI above, and using 4-methylphenylacetic acid (Aldrich) and L-alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

후처리

customThe reaction was monitored by tlc on silica gel and purification
filtrationwas by filtration

출처 및 근거

ORD 기록: ord-209596de7e474acba203eff5226a0931
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06849650B2

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