홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

2-Acetamidothiazole → 2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-(trifluoromethyl)-benzene propanamide

HRID 231143
노트
인쇄 미리보기

반응식

HRID 231143 반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7](=[O:9])[CH3:8].C([Li])CCC.[Cl:15][CH:16]([C:20]1[O:25][C:24](=[O:26])[C:23]2[CH:27]=[CH:28][CH:29]=[C:30]([C:31]([F:34])([F:33])[F:32])[C:22]=2[N:21]=1)[CH:17]([CH3:19])[CH3:18]>CCCCCC.O1CCCC1>[Cl:15][CH:16]([CH:17]([CH3:19])[CH3:18])[C:20]([NH:21][C:22]1[C:30]([C:31]([F:32])([F:33])[F:34])=[CH:29][CH:28]=[CH:27][C:23]=1[C:24](=[O:26])[CH2:8][C:7]([NH:6][C:2]1[S:1][CH:5]=[CH:4][N:3]=1)=[O:9])=[O:25]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 176252-AcetamidothiazoleHCID 136556172-(1-chloro-2-methylpropyl)-8-trifluoromethyl-4H-3,1-benzoxazine-4-oneHCID 178418339Butyllithium

생성물 1

HCID 134230872-[(2-chloro-1-oxo-3-methylbutyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-(trifluoromethyl)-benzene propanamide수율 82.6%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran
용매
2회
HCID 8058Hexane용매

실험 절차

10.6 g of N-(2-thiazolyl)-acetamide, 325 ml of tetrahydrofuran and 106 ml of n-butyllithium in hexane titrating 1.4M and 11.4 g of 2-(1-chloro-2-methylpropyl)-8-(trifluoromethyl)-4H-3,1-benzoxazin-4-one of Step A in solution in 80 ml of tetrahydrofuran were reacted by the procedure of Step A of Example 6 of Belgian Pat. No. 896,941 to obtain 13.8 g of 2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-3-(trifluoromethyl)-benzene propanamide melting at 186° C.

출처 및 근거

ORD 기록
ord-03d09dc8c672462badfb24ae11961c27
출처 데이터셋
uspto-grants-1989_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04845105

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트