Cyclopentylacetic acid → N-(cyclopentylacetyl)-L-alanine Iso-butyl Ester

반응식

[CH:1]1([CH2:6][C:7]([OH:9])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH2:18])[CH:12]([CH3:14])[CH3:13]>>[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH:18][C:7](=[O:9])[CH2:6][CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)[CH:12]([CH3:14])[CH3:13]

참가 물질

반응물 2

HCID 71606Cyclopentylacetic acid

HCID 865849812-Methylpropyl (2S)-2-aminopropanoate hydrochloride

생성물 1

HCID 54023872N-(cyclopentylacetyl)-L-alanine Iso-butyl Ester

실험 절차

Following General Procedure BB above, and using cyclopentylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 62° C.-64° C. The reaction was monitored by tlc on silica gel (Rf=0.37 in 1:3 EtOAc:hexane) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

후처리

customThe reaction was monitored by tlc on silica gel (Rf=0.37 in 1:3 EtOAc:hexane) and purification
extractionwas by extraction with Et2O

출처 및 근거

ORD 기록: ord-759f28cc195f45dcac582d3bf1a38aaf
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06849650B2

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