L-Alanine ethyl ester → N-[(2-phenyl)-2-fluoroacetyl]alanine Ethyl Ester

HRID 23117

반응식

[F:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=O.[CH2:12]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH2:17])[CH3:13]>>[CH2:12]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH:17][C:3](=[O:5])[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[F:1])[CH3:13]

참가 물질

반응물 2

HCID 76507L-Alanine ethyl ester

HCID 102649Fluorophenylacetic acid

생성물 1

HCID 22894970N-[(2-phenyl)-2-fluoroacetyl]alanine Ethyl Ester

실험 절차

Following General Procedure BF above, and using α-fluorophenyl acetic acid (Aldrich) and alanine ethyl ester (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.75 in 1:1 EtOAc:hexane) and purification was by chromatography on silica gel using 1:2 ethyl acetate/hexanes as the eluent.

후처리

customThe reaction was monitored by tlc on silica gel (Rf=0.75 in 1:1 EtOAc:hexane) and purification

출처 및 근거

ORD 기록: ord-a20da671143b4668b7975ef86c4cd6a2
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06849650B2

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