Potassium Carbonate → 3-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine

HRID 231179

반응식

HRID 231179 반응식
[N+:1]([N:4]=[C:5]1[NH:9][CH2:8][CH2:7][S:6]1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23]Cl)=[CH:19][N:18]=1>C(#N)C>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][N:9]2[CH2:8][CH2:7][S:6][C:5]2=[N:4][N+:1]([O-:3])=[O:2])=[CH:19][N:18]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 1362474392-Nitroiminothiazolidine

생성물 1

HCID 538802633-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 2.9 g of 2-nitroiminothiazolidine, 2.9 g of anhydrous potassium carbonate, 3.2 g of 2-chloro-5-pyridylmethylchloride and 50 ml of acetonitrile was refluxed for 5 hours with vigorously stirring. After the reaction, most of the acetonitrile was removed by distillation and water was added to the residue. As the solid product was separated, it was collected by filtration. The crude material was recrystallized from ethanol to give desired 3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine.

후처리

  1. temperaturewas refluxed for 5 hours
  2. customAfter the reaction
  3. custommost of the acetonitrile was removed by distillation and water
  4. additionwas added to the residue
  5. customAs the solid product was separated
  6. filtrationit was collected by filtration
  7. customThe crude material was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-bdf4c543cbc844858a7a65d3508b2046
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04845106

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